Cooling the skin for assessing small-fibre function
نویسندگان
چکیده
منابع مشابه
The diagnostic accuracy of Neuropad for assessing large and small fibre diabetic neuropathy.
AIMS Neuropad is a simple visual indicator test, with moderate diagnostic performance for diabetic peripheral neuropathy. As it assesses sweating, which is a measure of cholinergic small nerve fibre function, we compared its diagnostic performance against established measures of both large and, more specifically, small fibre damage in patients with diabetes. METHODS One hundred and twenty-sev...
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INTRODUCTION Patients with meralgia paresthetica (MP) usually experience not only paraesthesias and decreased tactile sensation, but also painful dysesthesias in the distribution of the lateral femoral cutaneous nerve (LFCN). We aimed at assessing whether there is any functional impairment of small fibres of the LFCN in patients with MP. METHODS We carried out a clinical, psychophysical and n...
متن کاملASSESSING THE EFFECT OF BLOCKAGE OF DIRT ON ENGINE RADIATOR IN THE ENGINE COOLING SYSTEM
This thesis looked at the effect of clay and silt soil blocking the heat transfer area of the radiator and its effect on the engine coolant through the conduct of experiments and a mathematical model developed. The results indicated that the percentage area covered resulted in a proportional increase of the inlet and outlet temperatures of the coolant in the radiator. The mathematically mode...
متن کاملUse of the novel contact heat evoked potential stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts
BACKGROUND The Contact Heat Evoked Potential Stimulator (CHEPS) rapidly stimulates cutaneous small nerve fibres, and resulting evoked potentials can be recorded from the scalp. We have studied patients with symptoms of sensory neuropathy and controls using CHEPS, and validated the findings using other objective measures of small nerve fibres i.e. the histamine-induced skin flare response and in...
متن کاملCooling-Sensitive TRPM8 Is Thermostat of Skin Temperature against Cooling
We have shown that cutaneous cooling-sensitive receptors can work as thermostats of skin temperature against cooling. However, molecule of the thermostat is not known. Here, we studied whether cooling-sensitive TRPM8 channels act as thermostats. TRPM8 in HEK293 cells generated output (y) when temperature (T) was below threshold of 28.4°C. Output (y) is given by two equations: At T >28.4°C, y = ...
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ژورنال
عنوان ژورنال: Pain
سال: 2019
ISSN: 0304-3959,1872-6623
DOI: 10.1097/j.pain.0000000000001584